Identity-as-a-Service: An Adaptive Security Infrastructure and Privacy-Preserving User Identity for the Cloud Environment

In recent years, enterprise applications have begun to migrate from a local hosting to a cloud provider and may have established a business-to-business relationship with each other manually. Adaptation of existing applications requires substantial implementation changes in individual architectural components. On the other hand, users may store their Personal Identifiable Information (PII) in the cloud environment so that cloud services may access and use it on demand. Even if cloud services specify their privacy policies, we cannot guarantee that they follow their policies and will not (accidentally) transfer PII to another party. In this paper, we present Identity-as-a-Service (IDaaS) as a trusted Identity and Access Management with two requirements: Firstly, IDaaS adapts trust between cloud services on demand. We move the trust relationship and identity propagation out of the application implementation and model them as a security topology. When the business comes up with a new e-commerce scenario, IDaaS uses the security topology to adapt a platform-specific security infrastructure for the given business scenario at runtime. Secondly, we protect the confidentiality of PII in federated security domains. We propose our Purpose-based Encryption to protect the disclosure of PII from intermediary entities in a business transaction and from untrusted hosts. Our solution is compliant with the General Data Protection Regulation and involves the least user interaction to prevent identity theft via the human link. The implementation can be easily adapted to existing Identity Management systems, and the performance is fast.</jats:p

In situ labeling of DNA reveals interindividual variation in nuclear DNA breakdown in hair and may be useful to predict success of forensic genotyping of hair

Hair fibers are formed by keratinocytes of the hair follicle in a process that involves the breakdown of the nucleus including DNA. Accordingly, DNA can be isolated with high yield from the hair bulb which contains living keratinocytes, whereas it is difficult to prepare from the distal portions of hair fibers and from shed hair. Nevertheless, forensic investigations are successful in a fraction of shed hair samples found at crime scenes. Here, we report that interindividual differences in the completeness of DNA removal from hair corneocytes are major determinants of DNA content and success rates of forensic investigations of hair. Distal hair samples were permeabilized with ammonia and incubated with the DNA-specific dye Hoechst 33258 to label DNA in situ. Residual nuclear DNA was visualized under the fluorescence microscope. Hair from some donors did not contain any stainable nuclei, whereas hair of other donors contained a variable number of DNA-positive nuclear remnants. The number of DNA-containing nuclear remnants per millimeter of hair correlated with the amount of DNA that could be extracted and amplified by quantitative PCR. When individual hairs were investigated, only hairs in which DNA could be labeled in situ gave positive results in short tandem repeat typing. This study reveals that the completeness of DNA degradation during cornification of the hair is a polymorphic trait. Furthermore, our results suggest that in situ labeling of DNA in hair may be useful for predicting the probability of success of forensic analysis of nuclear DNA in shed hair

Transient four-wave mixing in T-shaped GaAs quantum wires

The binding energy of excitons and biexcitons and the exciton dephasing in T-shaped GaAs quantum wires is investigated by transient four-wave mixing. The T-shaped structure is fabricated by cleaved-edge overgrowth, and its geometry is engineered to optimize the one-dimensional confinement. In this wire of 6.6×24 nm2 size, we find a one-dimensional confinement of more than 20 meV, an inhomogeneous broadening of 3.4 meV, an exciton binding energy of 12 meV, and a biexciton binding energy of 2.0 meV. A dispersion of the homogeneous linewidth within the inhomogeneous broadening due to phonon-assisted relaxation is observed. The exciton acoustic-phonon-scattering coefficient of 6.1±0.5 μeV/K is larger than in comparable quantum-well structures

Long-term outcome of patients with newly diagnosed chronic myeloid leukemia: a randomized comparison of stem cell transplantation with drug treatment.

Tyrosine kinase inhibitors represent today's treatment of choice in chronic myeloid leukemia (CML). Allogeneic hematopoietic stem cell transplantation (HSCT) is regarded as salvage therapy. This prospective randomized CML-study IIIA recruited 669 patients with newly diagnosed CML between July 1997 and January 2004 from 143 centers. Of these, 427 patients were considered eligible for HSCT and were randomized by availability of a matched family donor between primary HSCT (group A; N=166 patients) and best available drug treatment (group B; N=261). Primary end point was long-term survival. Survival probabilities were not different between groups A and B (10-year survival: 0.76 (95% confidence interval (CI): 0.69-0.82) vs 0.69 (95% CI: 0.61-0.76)), but influenced by disease and transplant risk. Patients with a low transplant risk showed superior survival compared with patients with high- (P&lt;0.001) and non-high-risk disease (P=0.047) in group B; after entering blast crisis, survival was not different with or without HSCT. Significantly more patients in group A were in molecular remission (56% vs 39%; P=0.005) and free of drug treatment (56% vs 6%; P&lt;0.001). Differences in symptoms and Karnofsky score were not significant. In the era of tyrosine kinase inhibitors, HSCT remains a valid option when both disease and transplant risk are considered

role of next generation sequencing technologies in personalized medicine

Following the completion of the Human Genome Project in 2003, research in oncology has progressively focused on the sequencing of cancer genomes, with the aim of better understanding the genetic basis of oncogenesis and identifying actionable alterations. The development of next-generation-sequencing (NGS) techniques, commercially available since 2006, allowed for a cost- and time-effective sequencing of tumor DNA, leading to a "genomic era" of cancer research and treatment. NGS provided a significant step forward in Personalized Medicine (PM) by enabling the detection of somatic driver mutations, resistance mechanisms, quantification of mutational burden, germline mutations, which settled the foundation of a new approach in cancer care. In this chapter, we discuss the history, available techniques, and applications of NGS in oncology, with a particular referral to the PM approach and the emerging role of the research field of pharmacogenomics

A Radiation Hardened 16 GS/s Arbitrary Waveform Generator IC for a Submillimeter Wave Chirp-Transform Spectrometer

This paper describes a radiation hardening design approach of a dual channel 16 GSps single chip arbitrary waveform generator (AWG) - a complex mixed-signal ASIC - that consists of a low phase noise 16 GHz PLL, two 1.6 Mbit SRAM blocks, two multiplexing chains, and two 4-bit DACs. The ASIC is dedicated to be a part of a submillimeter wave spectrometer that shall operate in deep-space environment. Under stringent power budget conditions, a selective radiation protection of the ASIC has been applied. The arbitrary waveform generator has been fabricated in a 130 nm SiGe BiCMOS process. Correct functionality has been verified in lab and will be further tested in an irradiation facility

A single chip 16 GS/s arbitrary waveform generator in 0.13 μm BiCMOS technology

This paper presents design considerations and measurements of a dual channel 16 GSps single chip arbitrary waveform generator. Each generator channel consists of a 1.6 Mbit SRAM block, a multiplexing chain, and a 4-bit DAC. A low phase noise 16 GHz PLL is integrated on the same chip. The prototype is designed to perform a lab experiment of a real-time SAW spectrometer. The overall power consumption of the chip is 1.45 W